Are there any known side-effects using glucosamine(1500mg/day) ?  

it may bring changes in insulin- resistence in the body

Answered by SANJAY88 , an ibibo Guru, at 10:46 AM on December 17, 2007

The dose recommended by manufacturers for glucosamine sulfate or chondroitin, is 500 mg daily. While it is not conclusively proved, excess dose may lead to Insulin-resistence in the body.

Answered by indianpedi , an ibibo Citizen, at 6:16 AM on December 17, 2007

People with diabetes should be a little cautious. Animal studies suggest a potential for raising blood sugar in some individuals. Otherwise, Glucosamine has an excellent safety record. A small number of users may experience mild GI upset, heartburn, nausea, diarrhea, and indigestion. This is usually solved by taking it with meals. Otherwise it is considered most effective when taken on an empty stomach.

Answered by satya , an ibibo Master, at 8:31 PM on December 16, 2007

Clinical studies of glucosamine have consistently reported that glucosamine appears safe. Since glucosamine is usually derived from shellfish, those allergic to shellfish may wish to avoid it. However, since glucosamine is derived from the shells of these animals while the allergen is within the flesh of the animals, it is probably safe even for those with shellfish allergy (Gray et al. 1994). Alternative sources using fungal fermentation of corn are available. Another concern has been that the extra glucosamine could contribute to diabetes by interfering with the normal regulation of the hexosamine biosynthesis pathway (Buse, 2006), but several investigations have found no evidence that this occurs (Scroggie et al., 2003).

Answered by Romi , an ibibo Master, at 8:30 PM on December 16, 2007