Biotechnology is unique amongst the three principal technologies for the twenty-first century — information technology, materials science, and biotechnology — in being a sustainable technology based on renewable biological resources. Such natural resources include animals, plants, yeasts, and microorganisms and have formed mankind's nascent food and beverage industry for several millennia. However, the modern era of scientific biotechnology commenced with the elucidation of the structure of DNA by Watson and Crick in 1953 and the subsequent development of the tools to cleave and resplice genetic material in the early 1970s. Not surprisingly, therefore, the term ‘biotechnology’ is generally considered synonymous with gene splicing and other forms of genetic engineering. In practice, however, biotechnology refers to a library of advanced scientific tools for the manipulation of biological organisms, systems, or components for the production of goods or services in all sectors of human activity.
The early years of the ‘new’ biotechnology focused on the technologies required to clone, overexpress, purify, and administer biopharmaceuticals such as insulin, growth hormone, factor VIII (deficient in haemophilia), and erythropoietin, with some 200 other proteins currently in the pipeline. However, in the future, the most significant breakthroughs in human medicine will result from mapping and understanding the human genome — in elucidating the exact sequence of the billions of nucleotides that constitute the estimated 30 000-40 000 genes that are the collective blueprint for human beings and are responsible for some 10 000 genetic disorders. The Human Genome Project was launched in 1990 as a 15-year, $3 billion international effort to map and sequence all human genes. Innovations in sequencing technology have ensured that the project moved ahead of schedule. With less than 5% of all human genes identified at the start of the project, it has become increasingly clear that each new gene discovery proffers new drugs for the diagnosis, treatment, and prevention of human disease. These drugs include therapeutic proteins, diagnostics, gene therapy reagents, and small molecules. A significant proportion of the human genome has been sequenced and many new human disease genes are being characterized. These advances will enable biotechnologists not only to measure disease potential and expand the applications for genomic diagnostics but also to devise fundamental new therapeutic approaches.
Genomics and genetic engineering are also playing a substantial role in the development of agricultural biotechnology. This sector is finally moving out from under the shadow of the biopharmaceutical community and is now competing in terms of publicity and investor attention. This is because $1 billion is considered an attractive market in the biopharmaceutical industry, whilst global agricultural markets can readily top $10 billion and the total end-use value of food, fibre, and biomass is estimated to be over $1500 billion. The addressable market on which value can be added and costs cut is at least 6-7 times that of its pharmaceutical counterpart. Two of the factors that have encouraged biotechnologists to enter the genetically engineered food and plant arena are the desire of consumers for better tasting foods and a preference for products grown using fewer pesticides. Calgene was the first company to market a genetically improved tomato which could be ripened on the vine without softening and thereby result in improved taste and texture. Antisense technology was used to inhibit the enzyme polygalacturonase which degrades pectin in the cell wall. Similarly, laurate Canola is the world's first oilseed crop that has been genetically engineered to modify oil composition. Laurate is the key raw material used in the manufacture of soap, detergent, food, oleochemical, and personal care products. Other examples of transgenic agricultural crops
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3:11 PM on July 26, 2008